Quick Answer
Gonorrhea has developed resistance to every antibiotic class used against it. Ceftriaxone is the only remaining first-line agent, and resistance is being monitored closely. Dual therapy (ceftriaxone + doxycycline) remains standard, and test-of-cure is recommended.
- Resistant to: penicillins, tetracyclines, fluoroquinolones, azithromycin
- Current: ceftriaxone 500mg IM single dose
- Surveillance: CDC GISP program monitors resistance
- Future: new antibiotics (gepotidacin, zoliflodacin) in development
Context Most Pages Skip
Antibiotic resistance in gonorrhea is one of the top public health threats. A completely untreatable gonorrhea infection is a real possibility.
The Resistance Timeline
Gonorrhea defeated every antibiotic class within 10-20 years of introduction. Ceftriaxone has held since 2010, but resistance is emerging. Test-of-cure 1-2 weeks after treatment is recommended.
⚕️ This page is educational and does not replace advice from a licensed clinician. If you may have been exposed to an STI, get tested — most infections are manageable, and many are fully curable.
Sources & Further Reading
- CDC — Sexually Transmitted Infections
- CDC STI Treatment Guidelines
- WHO — Sexually transmitted infections fact sheet
- MedlinePlus — Sexually Transmitted Diseases
Figures reflect CDC surveillance and WHO estimates; they are population statistics, not personal risk predictions.